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TPPB, Tocris Bioscience™

Product Code. 30000864
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Quantity:
1 mg
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This item is not returnable. View return policy

Description

High affinity PKC activator; also APP modulator

High affinity protein kinase C activator (Ki =11.9 nM). Induces differentiation of hESCs into Pdx-1 expressing pancreatic progenitor cells. Also enhances secretion of amyloid precursor protein. Cell permeable.

Specifications

CAS 497259-23-1
Molecular Formula C27H30F3N3O3
Linear Formula C27H30F3N3O3
Quantity 1 mg
Synonym tppb, alpha-app modulator, 2s,5s-e,e-8-5-4-trifluoromethyl phenyl-2,4-pentadienoylamino benzolactam, 2e,4e-n-2s,5s-1,2,3,4,5,6-hexahydro-5-hydroxymethyl-1-methyl-2-1-methylethyl-3-oxo-1,4-benzodiazocin-8-yl-5-4-trifluoromethyl phenyl-2,4-pentadienamide, 2e,4e-n-2s,5s-5-hydroxymethyl-2-isopropyl-1-methyl-3-oxo-2,4,5,6-tetrahydro-1,4-benzodiazocin-8-yl-5-4-trifluoromethyl phenyl penta-2,4-dienamide, 5-4-trifluoromethyl-phenyl-penta-2,4-dienoic acid 5-hydroxymethyl-2-isopropyl-1-methyl-3-oxo-1,2,3,4,5,6-hexahydro-benzo e 1,4 diazocin-8-yl-amide
Solubility Information Soluble to 50mM in DMSO
InChI Key WOLVEMPZUIFSII-IHHOKICGSA-N
SMILES CC(C)C1C(=O)NC(CC2=C(N1C)C=CC(=C2)NC(=O)C=CC=CC3=CC=C(C=C3)C(F)(F)F)CO
IUPAC Name (2E,4E)-N-[(2S,5S)-5-(hydroxymethyl)-1-methyl-3-oxo-2-propan-2-yl-2,4,5,6-tetrahydro-1,4-benzodiazocin-8-yl]-5-[4-(trifluoromethyl)phenyl]penta-2,4-dienamide
Molecular Weight (g/mol) 501.55
PubChem CID 9935767
Formula Weight 501.54
Physical Form Solid
Chemical Name or Material (2E,4E)-N-[(2S,5S)-1,2,3,4,5,6-Hexahydro-5-(hydroxymethyl)-1-methyl-2-(1-methylethyl)-3-oxo-1,4-benz
Grade >98%
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