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Trimethylacetyl chloride, 98+%, Thermo Scientific Chemicals

Product Code. 11431960
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Quantity:
100 mL
500 mL
2500 mL
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Regulatory: This product is an isolated intermediate transported in accordance with Regulation (EC) 1907/2006 (REACH). All customers must complete a declaration before delivery.
This item is not returnable. View return policy
Regulatory: This product is an isolated intermediate transported in accordance with Regulation (EC) 1907/2006 (REACH). All customers must complete a declaration before delivery.

Trimethylacetyl chloride is used as a precursor in the preparation of tert-butyl peroxypivalate, guttiferon A derivatives, which is potential for the treatment of malaria. It is used as a raw material in the production of synthetic acidamide medicament and phenol ester medicament. In addition to this, it is used for the synthesis of active pharmaceutical ingredients such as aminobenzylpenicilin, cephalexin, cefazolin, dipivefrin and dipivalyl epinephrine. It is also used in heavy polymerization, N-acylating agent for amines, Schiff bases, pyrrolidinones as well as an O-acylating agent for alcohols, lactones and saccharides.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Trimethylacetyl chloride is used as a precursor in the preparation of tert-butyl peroxypivalate, guttiferon A derivatives, which is potential for the treatment of malaria. It is used as a raw material in the production of synthetic acidamide medicament and phenol ester medicament. In addition to this, it is used for the synthesis of active pharmaceutical ingredients such as aminobenzylpenicilin, cephalexin, cefazolin, dipivefrin and dipivalyl epinephrine. It is also used in heavy polymerization, N-acylating agent for amines, Schiff bases, pyrrolidinones as well as an O-acylating agent for alcohols, lactones and saccharides.

Solubility
Miscible with acetonitrile.

Notes
Moisture sensitive. Incompatible withalcohols, oxidizing agents and strong bases.
TRUSTED_SUSTAINABILITY

Chemical Identifiers

CAS 3282-30-2
Molecular Formula C5H9ClO
Molecular Weight (g/mol) 120.58
MDL Number MFCD00000709
InChI Key JVSFQJZRHXAUGT-UHFFFAOYSA-N
Synonym pivaloyl chloride, trimethylacetyl chloride, propanoyl chloride, 2,2-dimethyl, pivalyl chloride, pivaloylchloride, 2,2-dimethylpropionyl chloride, pivalic acid chloride, pivalolyl chloride, unii-jq82j0o21t, 2,2-dimethylpropionylchloride
PubChem CID 62493
IUPAC Name 2,2-dimethylpropanoyl chloride
SMILES CC(C)(C)C(Cl)=O

Specifications

Melting Point -57°C
Density 0.985
Boiling Point 105°C to 106°C
Flash Point 8°C (46°F)
Odor Pungent
Refractive Index 1.412
Quantity 500 mL
UN Number UN2438
Beilstein 385668
Sensitivity Moisture sensitive
Solubility Information Miscible with acetonitrile.
Formula Weight 120.58
Percent Purity ≥98%
Chemical Name or Material Trimethylacetyl chloride
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Product Identifier
  • Trimethylacetyl chloride
Signal Word
  • Danger
Hazard Category
  • Acute toxicity Category 2
  • Acute toxicity Category 4
  • Serious eye damage/eye irritation Category 1
  • Flammable liquid Category 2
  • Substances and mixtures corrosive to metals Category 1
  • Skin corrosion/irritation Category 1 B
Hazard Statement
  • H225-Highly flammable liquid and vapour.
  • H290-May be corrosive to metals.
  • H302-Harmful if swallowed.
  • H314-Causes severe skin burns and eye damage.
  • H318-Causes serious eye damage.
  • H330-Fatal if inhaled.
Precautionary Statement
  • P210-Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking.
  • P280-Wear protective gloves/protective clothing/eye protection/face protection.
  • P301+P330+P331-IF SWALLOWED: rinse mouth. Do NOT induce vomiting.
  • P303+P361+P353-IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water/ shower.
  • P305+P351+P338-IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P310-Immediately call a POISON CENTER/doctor/.
Supplemental information
  • MIXTURE LIST-Contains : Pivaloyl chloride

RUO – Research Use Only

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