missing translation for 'onlineSavingsMsg'
Learn More
Learn More
Invitrogen™ WBSCR22 Polyclonal Antibody
Rabbit Polyclonal Antibody
Brand: Invitrogen™ PA521698
This item is not returnable.
View return policy
Description
Recommended positive controls: HeLa, HCT116, A375M. Predicted reactivity: Rhesus Monkey (99%), Bovine (83%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
The WBSCR22 gene, also known as Williams-Beuren Syndrome Chromosome Region 22, encodes a protein that participates in the biogenesis of the 40S ribosomal subunit. This gene is one of the 26 deleted in Williams-Beuren syndrome, which is characterized by cognitive delays, congenital heart and vascular diseases, and distinct facial features. WBSCR22 features a nuclear localization signal and an S-adenosylmethionine (SAM) binding motif typical of methyltransferases. The protein enhances cell survival and proliferation, with increased expression linked to poor prognosis in various cancers, including glioma and breast cancer. WBSCR22 modulates key signaling pathways such as Akt/GSK3B and beta-catenin/CyclinD1, and is a direct target of miR-146b-5p. Moreover, its downregulation suppresses tumor growth, suggesting its potential as a therapeutic target in oncology.
Specifications
| WBSCR22 | |
| Polyclonal | |
| Unconjugated | |
| BUD23 | |
| 1110003N24Rik; Bud site selection protein 23 homolog; BUD23; HASJ4442; HUSSY-03; HUSSY-3; MERM1; Metastasis-related methyltransferase 1; PP3381; Probable 18S rRNA (guanine-N(7))-methyltransferase; ribosome biogenesis methyltransferase WBSCR22; rRNA methyltransferase and ribosome maturation factor; WBMT; WBSCR22; Williams Beuren syndrome chromosome region 22; Williams-Beuren candidate region putative methyltransferase; Williams-Beuren syndrome chromosomal region 22 protein; Williams-Beuren syndrome chromosomal region 22 protein homolog; Williams-Beuren syndrome chromosome region 22 | |
| Rabbit | |
| Antigen affinity chromatography | |
| RUO | |
| 114049, 66138 | |
| Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
| Liquid |
| Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot, Immunocytochemistry | |
| 0.42 mg/mL | |
| 0.1M tris glycine with 10% glycerol and 0.01% thimerosal; pH 7 | |
| O43709, Q9CY21 | |
| BUD23 | |
| Recombinant protein encompassing a sequence within the center region of human WBSCR22. The exact sequence is proprietary. | |
| 100 μL | |
| Primary | |
| Human, Mouse | |
| Antibody | |
| IgG |
Product Content Correction
Your input is important to us. Please complete this form to provide feedback related to the content on this product.
Product Title
Spot an opportunity for improvement?Share a Content Correction