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Tocris Bioscience™ BIRB 796

High affinity and selective p38 kinase inhibitor

167.00 € - 610.00 €

Specifications

Chemical Name or Material N-[3-(1,1-Dimethylethyl)-1-(4-methylphenyl)-1H-pyrazol-5-yl]-N′-[4-[2-(4-morpholinyl)ethoxy]-1-naphthalenyl]urea
CAS 285983-48-4
Synonym Doramapimod
Target p38 Inhibitors
Molecular Formula C31H37N5O3
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Products 2
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Product Code Brand Quantity Price Quantity & Availability  
18757996
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Tocris Bioscience™
5989/10
10 mg
167.00 €
10mg
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18737196
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Tocris Bioscience™
5989/50
50 mg
610.00 €
50mg
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Description

Description

High affinity and selective p38 kinase inhibitor (Kd = 50-100 pM). Exhibits no significant inhibition on a panel of related kinases. Inhibits LPS-induced TNFα production in human PBMCs and whole blood (IC50 values are 21 and 960 nM, respectively). Also inhibits JNK2α2 and c-Raf-1 (IC50 values are 98 nM and 1.4 μM, respectively). Cell permeable.
Specifications

Specifications

N-[3-(1,1-Dimethylethyl)-1-(4-methylphenyl)-1H-pyrazol-5-yl]-N′-[4-[2-(4-morpholinyl)ethoxy]-1-naphthalenyl]urea
Doramapimod
C31H37N5O3
0.98
285983-48-4
p38 Inhibitors
527.66
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Safety and Handling

Safety and Handling

Recommended Storage : Store at -20°C

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