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Thermo Scientific™ CellSensor™ NFkB-bla ME-180 Cell Line

The CellSensor™ NFκB-bla ME-180 cell line contains a beta-lactamase reporter gene under control of the Nuclear Factor Kappa B (NFκB) response element stably integrated into ME-180 cells.

Brand:  Thermo Scientific™ K1667

Product Code. 10460014

  • 11620.00 € / Each

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For Research Use Only. All usage must comply with product instructions.

This item is not returnable. View return policy

Description

Description

The CellSensor™ NFκB-bla ME-180 cell line contains a beta-lactamase reporter gene under control of the Nuclear Factor Kappa B (NFκB) response element stably integrated into ME-180 cells. The cell line was created through fluorescence activated cell sorting (FACS) of cells responsive to stimulation of the NFκB pathway with tumor necrosis factor alpha (TNFα). The cell line was validated for DMSO tolerance, incubation time with stimulant, and substrate loading conditions. The CellSensor™ NFκB-bla ME-180 cell line responds to agonist treatment as expected from literature and can be adapted for high-throughput screening for agonists or antagonists of the NFκB pathway with compound libraries. Candidate drugs can also be tested for dose response against this cell line. Academic and non-profit customers, please inquire for special pricing.

TRUSTED_SUSTAINABILITY
Specifications

Specifications

Cell-based beta lactamase reporter gene
CellSensor™ Cell Lines are shipped on dry ice. Store in liquid nitrogen immediately upon receipt, or thaw for immediate use.
Fluorescent
beta-lactamase reporter gene under control of the nuclear factor Kappa B (NFkB) response element stably integrated into ME-180 cells
1 Vial
TNF alpha, NIK, TLR, I kappa B, IRAK, IKK, NF-kappa B pathway
ME-180
Signaling Pathway
Dividing Cells
CellSensor™ NFkB-bla ME-180 Cell Line, 1Vial, ∽ 9,600,000 cells/vial at 9,600,000 cells/mL Quantity of Cells, NFkB-bla ME-180 Cell Line, Fluorescent Detection Method, CellSensor™ Druggable Target, Adherent Growth Properties, Liquid Nitrogen Storage
Pharma and biopharma, drug discovery and development, target and lead identification and validation, pathway biology, cellular pathway analysis assays, cellsensor™ cellular pathway assays
CellSensor™
NFkB-bla ME-180
Cell Line
CellSensor™
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Lot Number Certificate Type Date Catalog Number
Lot Number453960 Certificate TypeCertificate of Analysis Date15/04/2017 Catalog NumberK1667
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For Research Use Only. Not for use in diagnostic procedures.