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Thermo Scientific™ GeneBLAzer™ ENDRB-NFAT-bla HEK 293T Cells

GeneBLAzer™ EDNRB-NFAT-bla HEK293T cells contain the human Endothelin Type B Recpetor (EDNRB) stably integrated into the CellSensor™ NFAT-bla HEK293T cell line.

Brand: Thermo Scientific™ K1727

Product Code. 10542764

16470.00 € / Each

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For Research Use Only. All usage must comply with product instructions.

This item is not returnable. View return policy

Description

GeneBLAzer™ EDNRB-NFAT-bla HEK293T cells contain the human Endothelin Type B Recpetor (EDNRB) stably integrated into the CellSensor™ NFAT-bla HEK293T cell line. CellSensor™ NFAT-bla HEK293T cells (Cat. No. K1538) contain a beta-lactamase reporter gene under control of the Nuclear Factor of Activated T-cells (NFAT) response element.

The GeneBLAzer™ EDNRB-NFAT-bla HEK293T cells are functionally validated for Z' and EC₅₀ concentrations of ET-1. In addition, GeneBLAzer™ EDNRB-NFAT-bla HEK293T cells have been tested for assay performance under variable conditions. These data are found in the Validation & Assay Performance Summary.

The ENDRB receptor mediates signaling of endothelin proteins that regulate several critical biological processes, including the development and function of blood vessels, the production of certain hormones, and the stimulation of cell growth and division. Defects in EDNRB mediated signaling have been implicated in a wide range of diseases, including cancer, hypertension and cardiovascular disorders.

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Specifications

Accession Number	NM_000115.1
Cell State	Dividing Cells
Detection Method	Fluorescence
Gene Symbol	EDNRB
Population Status	Single Cell Clone Origin
Quantity	2 x 10⁶ Cells
Target Entry	EDNRB
Cell Line	293T (HEK)
Druggable Target	GPCR

Assay Entry	Cell-based beta lactamase reporter gene
Content And Storage	LiveBLAzer™-FRET B/G Loading Kit, Solution D and other materials are required separately; please refer to the protocol. Includes: • GeneBLAzer™ EDNRB-NFAT-bla HEK293T cells • GeneBLAzer™ EDNRB-NFAT-bla HEK293T Assay Protocol • Certificate of Analysis The GeneBLAzer™ GeneBLAzer™ EDNRB-NFAT-bla HEK293T cells are shipped on dry ice and should be stored in liquid nitrogen immediately upon receipt.
For Use With (Application)	FRET
Includes	EDNRB-NFAT-bla HEK293T cells, EDNRB-NFAT-bla HEK293T Assay Protocol, Certificate of Analysis
Product Line	GeneBLAzer™
Reporter Gene	BLA (Beta-Lactamase)
Type	Cell Line
System Type	GeneBLAzer™

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Lot Number

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Lot Number	Certificate Type	Date	Catalog Number
Lot Number36277	Certificate TypeCertificate of Analysis	Date15/04/2017	Catalog NumberK1727

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Thermo Scientific™ GeneBLAzer™ ENDRB-NFAT-bla HEK 293T Cells

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