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Invitrogen™ Human ErbB2 (HER-2) Fc Chimera Recombinant Protein

Recombinant Protein

342.00 € - 2210.00 €

Specifications

Accession Number	P04626
Concentration	0.83 mg/mL
For Use With (Application)	ELISA, Functional Assay
Format	Lyophilized
Formulation	PBS with 0.01% Tween 80, 5% mannitol, 5% trehalose and no preservative; pH 7.4

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Products 2

Product Code	Brand	Quantity	Price	Quantity & Availability
Product Code	Brand	Quantity	Price	Quantity & Availability
17946331 View Documents missing translation for 'viewProductCertificates'	Invitrogen™ RP88054	100 μg	342.00 € 100µg		Please sign in to purchase this item. Need a web account? Register with us today!

17916441 View Documents missing translation for 'viewProductCertificates'	Invitrogen™ RP88055	1 mg	2210.00 € 1mg		Please sign in to purchase this item. Need a web account? Register with us today!

Description

It is recommended that the protein be aliquoted for optimal storage. It is recommended that sterile water (1695 μL) be added to the vial to prepare a stock solution of 0.83 mg/mL. Concentration is measured by UV.

ErbB2 (HER2) is a receptor tyrosine kinase that is overexpressed in some breast tumors. Herceptin, used in treatment of metastatic Her2-positive cancer, is monoclonal antibody targeting this kinase.

Specifications

Accession Number	P04626
For Use With (Application)	ELISA, Functional Assay
Formulation	PBS with 0.01% Tween 80, 5% mannitol, 5% trehalose and no preservative; pH 7.4
Molecular Weight (g/mol)	130-140 kDa
Purification Method	SDS-PAGE
Endotoxin Concentration	<1.0 EU/ μg
Common Name	Her-2 (ErbB2)
Biological Activity	1. Immobilized Her2/ERBB2 Protein, Human, Recombinant (ECD, hFc Tag) (at 2 μg/ml (100 μL/well) can bind Anti-Erbb2 Antibody (Trastuzumab), the EC50 is 16-80 ng/mL 2. Measured by its ability to block anti-ErbB2 mediated inhibition of BT474 human breast ductal carcinoma cell proliferation. The ED50 for this effect is 0.5-3 μg/mL in the presence of 0.6 μg/mL Anti-ErbB2/Her2 Monoclonal Antibody.)
Conjugate	Unconjugated
Protein Tag	Fc-tag
Content And Storage	-20°C, Avoid Freeze/Thaw Cycles
Expression System	HEK293 cells
Purity or Quality Grade	≥90% as determined by SDS-PAGE. ≥90% as determined by SEC-HPLC.

Concentration	0.83 mg/mL
Format	Lyophilized
Gene ID (Entrez)	2064
Name	Human ErbB2 (HER-2) Fc Chimera
Regulatory Status	RUO
Gene Alias	avian erythroblastosis oncogene B 2; Avian erythroblastosis viral (v-erb-B2) oncogene homologue 2 (neuro/glioblastoma derived oncogene homolog); CD antigen CD340; CD340; c-erb B2/neu protein; c-erbB2; C-erbB-2; c-neu; epidermal growth factor receptor-related protein; erbb 2; ERBB2; erb-b2; Erbb-2; ErbB2 (pTyr1139); ErbB2 (pY1139); ErbB2 phospho Y1139; erb-b2 receptor tyrosine kinase 2; her 2; HER2; HER-2; HER-2/neu; herstatin; human epidermal growth factor receptor 2; Kiaa3023; metas; Metastatic lymph node gene 19 protein; mKIAA3023; MLN 19; MLN19; NEU; Neu oncogene; NEU proto-oncogene; neuro/glioblastoma derived oncogene homolog; neuroblastoma/glioblastoma derived oncogene homolog; NGL; p185erbB2; p185neu; phospho ErbB2; proto-oncogene c-ErbB-2; Proto-oncogene Neu; receptor tyrosine-protein kinase erbB-2; TKR1; Tyrosine kinase-type cell surface receptor HER2; v-erb-b2 avian erythroblastic leukemia viral oncogene 2; v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2; v-erb-b2 avian erythroblastic leukemia viral oncoprotein 2; v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog; v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)
Gene Symbol	ERBB2
Product Type	Protein
Recombinant	Recombinant
Sequence	Human ErbB2, amino acids Met1-Thr652 (Accession # NP_004439.2) with a C-terminal human IgG1 Fc region
Activity	1. Immobilized Her2/ERBB2 Protein, Human, Recombinant (ECD, hFc Tag) (at 2 μg/ml (100 μL/well) can bind Anti-Erbb2 Antibody (Trastuzumab), the EC50 is 16-80 ng/mL 2. Measured by its ability to block anti-ErbB2 mediated inhibition of BT474 human breast ductal carcinoma cell proliferation. The ED50 for this effect is 0.5-3 μg/mL in the presence of 0.6 μg/mL Anti-ErbB2/Her2 Monoclonal Antibody.)
Form	Lyophilized

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Invitrogen™ Human ErbB2 (HER-2) Fc Chimera Recombinant Protein

Specifications

Description

Specifications

Documents