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Proteintech™ Human TDP-43 ELISA Kit

KE00009 is a solid phase sandwich Enzyme Linked-Immuno-Sorbent Assay (Sandwich ELISA) and is to be used to detect and quantify protein levels of endogenous TDP-43

Brand:  Proteintech™ KE00009-96T


Product Code. 16891436

  • 520.00 € / 96 tests

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Description

Description

  • TARDBP was firstly found as a transcriptional repressor that binds to chromosomally integrated TAR DNA and represses HIV-1 transcription. It was also reported to regulate alternate splicing of the CFTR gene.
  • Neumann et al. (2006) found that a hyperphosphorylated, ubiquitinated, and cleaved form of TARDBP, known as pathologic TDP43, is the major disease protein in ubiquitin-positive, tau-, and alpha-synuclein-negative frontotemporal dementia (FTLD-U) and in Amyotrophic lateral sclerosis (ALS).
  • KE00009 is used to quantify TDP-43 level in vivo and it is suitable for sample of CSF and cell lysates.
  • KE00005 is used to quantify TDP-43 level in vivo and it is suitable for sample of serum or plasma.
  • The assay recognizes human TDP-43. An antibody specific for TDP-43 has been pre-coated onto the microwells. The TDP-43 protein in samples is captured by the coated antibody after incubation.
  • Following extensive washing, another antibody of biotinylated specific for TDP-43 is added to detect the captured TDP-43 protein.
  • For signal development, Streptavidin-HRP is added, followed by Tetramethyl-benzidine (TMB) reagent.
  • Solution containing sulfuric acid is used to stop color development and the color intensity which is proportional to the quantity of bound protein is measurable at 450 nm with the correction wavelength set at 630 nm.
Specifications

Specifications

BC001487
0.26 ng/mL
Sandwich ELISA, Double Antibody
Plasma, Serum
Human
Human
<10%
Blue ice
4.5 hr.
6.25 to 400 ng/mL
ISO 13485
Coated ELISA Kit
DAB
23435
Solid
<10%
-20°C to +4°C
Q13148
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