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KN-62, MedChemExpress

MedChemExpress KN-62 is a selective and reversible inhibitor of calmodulin-dependent protein kinase II (CaMK-II) with a Ki of 0.9 μM for rat brain CaMK-II. KN-62 directly binds to the calmodulin binding site of CaMK-II. KN-62 displays noncompetitive antagonism at P2X7 receptors in HEK293 cells, with an IC50 value of approximately 15 nM.

Brand: Medchem Express HY-13290

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Product Code. 16478317

122.85 € / 5mg

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Description

KN-62 is a selective and reversible inhibitor of calmodulin-dependent protein kinase II (CaMK-II) with a Ki of 0.9 μM for rat brain CaMK-II. KN-62 directly binds to the calmodulin binding site of CaMK-II. KN-62 displays noncompetitive antagonism at P2X7 receptors in HEK293 cells, with an IC50 value of approximately 15 nM.

Specifications

Chemical Name or Material	KN-62
Color	Yellow
Molecular Formula	C₃₈H₃₅N₅O₆S₂
Solubility Information	DMSO : ≥ 100 mg/mL (138.53 mM)
Molecular Weight (g/mol)	721.84
Percent Purity	98.27%
Physical Form	Powder

CAS	127191-97-3
Purity Grade Notes	Research
Quantity	5 mg
SMILES	O=C(N1CCN(C2=CC=CC=C2)CC1)[C@H](CC3=CC=C(C=C3)OS(=O)(C4=CC=CC5=C4C=CN=C5)=O)N(C)S(=O)(C6=CC=CC7=C6C=CN=C7)=O
Formula Weight	721.84
Grade	Research
For Use With (Application)	Cancer-Kinase/protease

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KN-62, MedChemExpress

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